The Battle of the Platelets: PRP vs PRF Explained

If you’ve spent any time around medical spas lately, you’ve probably heard the buzzwords PRP and PRF. They’re often mentioned in the same breath as microneedling, under-eye rejuvenation, and “natural” skin treatments. But what exactly are they? How are they different? And, more importantly, which one is right for you?

At Colorado Beauty RN, we know that the world of regenerative aesthetics can feel overwhelming, especially when you’re deciding where to invest your time, money, and trust. That’s why we believe in breaking down complex treatments into clear, honest guidance. So, let’s dive into the battle of the platelets: PRP vs. PRF.

First Things First: What Are PRP and PRF?

Both PRP (Platelet-Rich Plasma) and PRF (Platelet-Rich Fibrin) are treatments that use your own blood to stimulate healing, collagen production, and rejuvenation. Think of them as natural ways to “hack” your body’s repair system for beauty and anti-aging.

Here’s how it works:

• A small sample of your blood is drawn (just like at a routine lab).
  
  

• That sample is spun in a centrifuge to separate its components.
  
  

• The resulting concentrate, rich in platelets and growth factors, is used to boost skin regeneration when combined with treatments like microneedling or injected into targeted areas.
  
  

The difference lies in how they’re processed and what’s in that final concentrate.

PRP: The Original Player

PRP has been around for decades. Originally used in orthopedics and sports medicine to speed up healing, it’s made its way into aesthetics for skin and hair rejuvenation.

How it works:

• Blood is spun at a higher speed, separating plasma from red and white blood cells.
  
  

• The result is plasma packed with platelets and growth factors.
  
  

• This plasma is then applied or injected to stimulate collagen, improve skin tone, and promote healing.
  
  

Benefits of PRP:

• Improves skin texture and tone
  
  

• Stimulates collagen production
  
  

• Reduces fine lines and wrinkles
  
  

• Helps with acne scars
  
  

• Can encourage hair growth when injected into the scalp
  
  

PRP has earned its reputation as a solid, science-backed treatment. But like many things in aesthetics, innovation never stops and that’s where PRF comes in.

PRF: The Next Generation

PRF, or Platelet-Rich Fibrin, is often described as the “upgrade” to PRP. While PRP is already powerful, PRF takes the process a step further to unlock even more natural benefits.

How it works:

• Blood is spun at a lower speed than with PRP.
  
  

• This gentler process allows more platelets, white blood cells, and stem cells to remain in the plasma.
  
  

• Because it’s not mixed with anticoagulants, the PRF forms a fibrin matrix—a gel-like substance—that holds and slowly releases growth factors over time.
  
  

Benefits of PRF:

• Longer-lasting release of growth factors (up to 10–12 days vs. PRP’s quick release)
  
  

• Contains stem cells for added regenerative power
  
  

• Creates a natural scaffold that supports tissue regeneration
  
  

• Excellent for under-eye hollows, where delicate skin needs subtle, natural improvement
  
  

• Can be combined with microneedling for enhanced rejuvenation
  
  

In short: PRF doesn’t just give your skin a quick boost. It gives you a slower, more sustained release of healing factors, meaning more natural, longer-lasting results.

Key Differences at a Glance

Think of PRP and PRF like two different versions of your favorite skincare serum: both are effective, but one might give you that extra something special.

Which One Should You Choose?

The answer depends on your goals, timeline, and budget.

• Choose PRP if…
  You’re looking for a proven, effective treatment to improve skin texture, tone, and overall glow. PRP is also a great choice if you’re addressing hair thinning or want an entry point into regenerative aesthetics.
  
  

• Choose PRF if…
  You want the latest generation of platelet therapy with more natural components, a longer-lasting effect, and the added regenerative benefits of stem cells. PRF shines for delicate areas (like under the eyes) or when you’re looking for next-level rejuvenation.
  
  

At Colorado Beauty RN, we often recommend PRF for clients who have already explored other treatments and are ready for a more advanced option. It’s like moving from your reliable skincare routine to a luxury upgrade, it takes everything you love and amplifies it.

Common Questions About PRP and PRF

“Does it hurt?”
Both treatments involve small injections. We use numbing cream and gentle techniques to keep you comfortable. Most patients describe it as tolerable.

“Is there downtime?”
You may experience redness or mild swelling for 1–3 days, especially when combined with microneedling. Most moms schedule treatments when they can afford a quiet evening or weekend to recover.

“How many treatments will I need?”
Both PRP and PRF usually require a series, typically 3 sessions, spaced about a month apart for best results. Maintenance treatments once or twice a year keep results going strong.

“Is it safe?”
Yes. Because these treatments use your own blood, the risk of allergic reactions is minimal. As with any procedure, it’s important to choose a qualified provider who follows medical protocols.

Why Patients Love These Treatments

We hear it all the time: “I finally look like I feel.”

PRP and PRF are popular because they’re natural, subtle, and effective. Instead of freezing your expressions or drastically changing your features, these treatments work with your body’s natural healing to restore vibrancy.

Many of our patients love that friends and family notice they “look refreshed” but can’t pinpoint why. That’s the beauty of regenerative aesthetics, it’s all about enhancing what you already have.

The Emotional Side of Regeneration

For women between 35 and 55, skin concerns often hit at the same time life feels the busiest. You’re balancing family, career, and maybe even aging parents. The last thing you want is to look in the mirror and feel like your reflection doesn’t match your energy.

PRP and PRF offer a solution that’s not about vanity, it’s about confidence. It’s about waking up, putting on less makeup, and feeling good in your skin. It’s about looking rested even when life is anything but restful.

Why Choose Colorado Beauty RN for PRP and PRF

Here’s why our patients trust us:

• Medical Expertise: Treatments are performed under medical oversight with FDA-approved devices and protocols.
  
  

• Personalized Plans: We take the time to understand your goals, budget, and lifestyle before recommending a treatment.
  
  

• Honest Guidance: We won’t push what you don’t need. If PRP is the right fit, we’ll tell you. If PRF will serve you better, we’ll explain why.
  
  

• Small-Town Heart, Big-Time Results: Our approach is warm, approachable, and results-driven.
  
  

At the end of the day, our mission is to guide—not pressure—you into treatments that genuinely improve your confidence and quality of life.

Final Thoughts

In the battle of the platelets, there’s no “bad” choice. Both PRP and PRF harness your body’s natural power to rejuvenate skin, reduce signs of aging, and restore confidence.

PRP is the tried-and-true veteran—reliable, effective, and still a fantastic option. PRF is the next-generation upgrade, offering a longer-lasting, more natural release of regenerative factors.

If you’re ready to explore either treatment, we’d love to guide you through the process. Because at Colorado Beauty RN, it’s not just about what’s trending—it’s about what works for you.

👉 Book your consultation today to learn more about PRP vs. PRF and discover which one is your perfect match.

✨ Want to see PRP in action? Watch our behind-the-scenes treatment video here → The Battle of the Platelets.